(2R,5R)-2,5-Dibenzyl-6-((4S,7S,10aS)-7-(methoxycarbonyl)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-ylamino)-6-oxohexanoic acid → (4S,7S,10aS)-Methyl 4-((2R,5R)-2,5-dibenzyl-6-oxo-6-((S)-2-oxo-1-phenylpiperidin-3-ylamino)hexanamido)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate

Participants

Reaction Steps

(4S,7S,10aS)-Methyl 4-((2R,5R)-2,5-dibenzyl-6-oxo-6-((S)-2-oxo-1-phenylpiperidin-3-ylamino)hexanamido)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate was synthesized as described in General Procedure H using Intermediate 23 (10 mg, 0.018 mmol) and Intermediate 32 (3.4 mg, 0.018 mmol) to give a white solid (5.0 mg, 36% yield). Anal. Calcd. for C42H50N4O6S m/z 738.4. found: 739.4 (M+H)+; 1H NMR (500 MHz, CD3OD) δ ppm 7.46-7.35 (m, 2H), 7.32-7.25 (m, 3H), 7.23-7.08 (m, 10H), 5.49 (dd, J=6.32, 3.02 Hz, 1H), 5.08-5.02 (m, 1H), 4.98-4.91 (m, 1H), 4.17 (dd, J=11.00, 6.05 Hz, 1H), 3.97 (s, 1H), 3.73 (d, J=7.15 Hz, 1H), 3.64 (s, 3H), 3.09 (s, 1H), 2.89-2.76 (m, 2H), 2.76-2.65 (m, 3H), 2.65-2.51 (m, 2H), 2.31 (br. s., 1H), 2.11-1.91 (m, 5H), 1.90-1.80 (m, 1H), 1.77-1.55 (m, 7H), 1.57-1.46 (m, 2H).

Provenance & Evidence