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HRID529579

反应详情

EQUATION

反应方程式

HRID 529579 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)CCCN(c2ccccc2)C(=O)C1N
HCID68291697

未命名化合物

结构：COC(=O)[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)[C@H](CC[C@H](Cc3ccccc3)C(=O)O)Cc3ccccc3)C(=O)N21
HCID68311179

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)[C@H](CC[C@H](Cc3ccccc3)C(=O)N[C@@H]3C(=O)N(c4ccccc4)CCCC3(C)C)Cc3ccccc3)C(=O)N21
HCID68309859

未命名化合物

PROCEDURE

实验过程

(4S,7S,10aS)-Methyl 4-((2R,5R)-2,5-dibenzyl-6-((S)-4,4-dimethyl-2-oxo-1-phenylazepan-3-ylamino)-6-oxohexanamido)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate was synthesized as described in General Procedure H using Intermediate 23 (10 mg, 0.018 mmol) and Intermediate 34 (4.1 mg, 0.018 mmol) to give a white solid (4.0 mg, 27% yield). Anal. Calcd. for C45H56N4O6S m/z 780.4. found: 781.5 (M+H)+; 1H NMR (500 MHz, CD3OD) δ ppm 7.32 (t, J=7.70 Hz, 2H), 7.28-7.10 (m, 11H), 7.00 (d, J=7.70 Hz, 2H), 5.52 (dd, J=6.05, 2.75 Hz, 1H), 5.07-4.97 (m, 2H), 4.94-4.88 (m, 1H), 4.12-4.00 (m, 1H), 3.60 (s, 3H), 3.58-3.51 (m, 1H), 2.98-2.82 (m, 2H), 2.82-2.63 (m, 5H), 2.59-2.50 (m, 1H), 2.38-2.27 (m, 1H), 2.13-2.02 (m, 1H), 1.97 (br. s., 2H), 1.86-1.75 (m, 3H), 1.75-1.55 (m, 7H), 1.48 (s, 1H), 1.32-1.24 (m, 1H), 0.80 (s, 3H), 0.45 (s, 3H).