反应详情

(2R,5R)-2,5-Dibenzyl-N1-((4R,7S,10aS)-5-oxo-7-(thiazol-2-ylcarbamoyl)octahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-yl)-N6-((4S,7S,10aS)-5-oxo-7-(thiazol-2-ylcarbamoyl)octahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-yl)hexanediamide was synthesized as described in General Procedure F using Intermediate 3 (10 mg, 0.031 mmol) and Intermediate 37 (25 mg, 0.069 mmol) to give a white solid (14 mg, 46% yield). Anal. Calcd. for C46H54N8O6S4 m/z 942.7. found: 943.5 (M+H)+; 1H NMR (400 MHz, CDCl3) δ ppm 7.21-7.11 (m, 14H), 5.38 (br s, 2H), 5.11 (m, 4H), 3.15 (m, 2H), 2.76 (m, 6H), 2.36 (m, 4H), 2.12 (m, 4H), 1.85-1.40 (m, 14H).