Reaction Steps
(4S,7S,10aS)-Methyl 4-((2R,5R)-2,5-dibenzyl-6-oxo-6-((S)-2-oxo-1-(pyridin-3-ylmethyl)azepan-3-ylamino)hexanamido)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate was synthesized as described in General Procedure H using Intermediate 23 (7.0 mg, 0.012 mmol) and Intermediate 41 (4.4 mg, 0.020 mmol) to give a white solid (4.5 mg, 47% yield). Anal. Calcd. for C43H53N5O6S m/z 767.7. found: 768.7 (M+H)+; 1H NMR (500 MHz, CDCl3) δ ppm 8.79 (br. s., 1H), 8.69 (d, J=4.95 Hz, 1H), 8.11 (d, J=7.70 Hz, 1H), 7.70 (dd, J=7.70, 5.50 Hz, 1H), 7.22 (t, J=7.42 Hz, 4H), 7.19-7.10 (m, 6H), 6.98 (d, J=6.60 Hz, 1H), 6.79 (d, J=6.60 Hz, 1H), 5.35-5.28 (m, 1H), 5.15-5.08 (m, 1H), 4.98 (br. s., 1H), 4.88 (d, J=15.40 Hz, 1H), 4.68-4.57 (m, 1H), 4.44 (d, J=15.40 Hz, 1H), 3.67 (s, 3H), 3.60 (dd, J=15.12, 11.82 Hz, 1H), 3.29-3.10 (m, 2H), 2.84-2.77 (m, 3H), 2.77-2.67 (m, 2H), 2.04-1.97 (m, 2H), 1.90-1.48 (m, 13H), 1.26 (t, J=7.15 Hz, 2H), 1.13 (d, J=13.20 Hz, 2H).
