(2R,5R)-2,5-dibenzyl-6-oxo-6-((R)-2-oxo-1-phenylazepan-3-ylamino)hexanoic acid → (2R,5R)-2,5-Dibenzyl-N1-((S)-2-oxo-1-phenylazepan-3-yl)-N6-((4S,10aS)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-yl)hexanediamide

Participants

Reaction Steps

(2R,5R)-2,5-Dibenzyl-N1-((S)-2-oxo-1-phenylazepan-3-yl)-N6-((4S,10aS)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-yl)hexanediamide was synthesized as described in General Procedure H using Intermediate 24 (20 mg, 0.039 mmol) and Intermediate 40 (10 mg, 0.051 mmol) to give a white solid (16 mg, 58% yield). Anal. Calcd. for C41H50N4O4S m/z 694.4. found: 695.3 (M+H)+; 1H NMR (400 MHz, DMSO-d6) δ ppm 7.76 (dd, J=18.7, 7.1 Hz, 2H), 7.35 (t, J=7.8 Hz, 2H), 7.29-7.03 (m, 11H), 5.60 (s, 1H), 5.04-4.85 (m, 1H), 4.76-4.59 (m, 1H), 4.08 (d, J=13.2 Hz, 1H), 3.95 (dd, J=15.3, 11.5 Hz, 1H), 3.52 (d, J=15.9 Hz, 1H), 3.07 (t, J=11.3 Hz, 1H), 2.87-2.35 (m, 11H), 2.08-1.01 (m, 17H).

Provenance & Evidence