反应详情

温度

60 °C

A suspension of 1.65 g of 4-(1-hydroxy-2,2-dimethyl propyl)-2-propyl-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carbonitrile [prepared as described in step (b) above] in 24 ml of 75% v/v aqueous acetic acid was stirred at 60° C. for 2 hours. At the end of this time, 6 ml of water was added to the reaction mixture, which was then cooled with ice. The trityl alcohol which precipitated was removed by filtration, and the filtrate was concentrated by evaporation under reduced pressure, to give 1.07 g of the title compound as a glass.

1. temperaturewas then cooled with ice
2. customThe trityl alcohol which precipitated
3. customwas removed by filtration
4. concentrationthe filtrate was concentrated by evaporation under reduced pressure