Aluminium lithium hydride → HCID 86679333, compound

Participants

Reaction Steps

About 0.022 mole of lithium aluminum hydride may be stirred into about 50 milliliters of anhydrous THF to make a slurry under an inert atmosphere, and cooled in an ice bath. About 0.01 mole of 3-(naphth-2-yl)-2,5-diformylthiophene may be dissolved in about 10 milliliters of anhydrous THF and added to the slurry with stirring. The reaction may be stirred and allowed to rise to room temperature, and then refluxed for about 2 hours. The reaction mixture may be cooled, carefully quenched with about 50 milliliters of water and washed with about 0.1 M sodium hydroxide. The organic layer may be dried, and the solvent may be removed to leave a residue. The residue may be purified via silica gel chromatography to give (3-(naphthalen-2-yl)thiophene-2,5-diyl)dimethanol.

Provenance & Evidence