2-(Azidomethyl)furan → HCID 178479118, 화합물

HRID 529891노트

반응식

HRID 529891 반응식
[ClH:1].[CH2:2]([C:5]1[N:6]=[C:7]([NH2:10])[NH:8][CH:9]=1)[C:3]#[CH:4].[N:11]([CH2:14][C:15]1[O:16][CH:17]=[CH:18][CH:19]=1)=[N+:12]=[N-:13]>>[ClH:1].[O:16]1[CH:17]=[CH:18][CH:19]=[C:15]1[CH2:14][N:11]1[CH:4]=[C:3]([CH2:2][C:5]2[N:6]=[C:7]([NH2:10])[NH:8][CH:9]=2)[N:13]=[N:12]1

참가 물질

3

반응물 2

HCID 233157982-(Azidomethyl)furanHCID 178439632HCID 178439632, 화합물

생성물 1

HCID 178479118HCID 178479118, 화합물수율 455.5%

실험 절차

4-Prop-2-ynyl-1H-imidazol-2-ylamine hydrochloride (0.096 g, 0.061 mmol) was reacted with 2-azidomethyl-furan (0.089 g, 0.729 mmol) following the general procedure for click reactions outlined above to produce 4-(1-Furan-2-ylmethyl-1H-[1,2,3]triazol-4-ylmethyl)-1H-imidazol-2-ylamine hydrochloride (0.078 g, 46%) as a pale yellow solid. 1H NMR (300 MHz, CD3OD) δ 7.93 (s, 1H), δ 7.41 (s, 1H), 6.49 (s, 2H), δ 6.32 (s, 1H), δ 5.56 (s, 2H), δ 3.89 (s, 2H) ppm; 13C NMR (75 MHz, CD3OD) δ 146.2, 146.1, 142.4, 141.5, 122.3, 122.2, 108.9, 109.2, 108.8, 51.6, 18.9 ppm; HRMS (ESI) calcd for C11H12N6O (M+) 245.1145. found 245.1147.

출처 및 근거

ORD 기록
ord-d7ec48be7e63425cb3f18d5d0b82721b
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09351491B2

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