2-Amino-4-hept-6-ynyl-imidazole-1-carboxylic acid tert-butyl ester → HCID 90843541, compound

HRID 529957Notes

Reaction equation

HRID 529957 reaction equation
[NH2:1][C:2]1[N:3]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH:4]=[C:5]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]#[CH:13])[N:6]=1.[N:21]([CH2:24][CH2:25][NH:26][C:27](=[O:35])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[I:34])=[N+:22]=[N-:23]>>[NH2:1][C:2]1[N:3]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH:4]=[C:5]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]2[N:23]=[N:22][N:21]([CH2:24][CH2:25][NH:26][C:27](=[O:35])[C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[I:34])[CH:13]=2)[N:6]=1

Participants

3

Reactant 2

HCID 533595342-Amino-4-hept-6-ynyl-imidazole-1-carboxylic acid tert-butyl esterHCID 55136529HCID 55136529, compound

Product 1

HCID 90843541HCID 90843541, compound

Procedure

tert-butyl 2-amino-4-(hept-6-ynyl)-1H-imidazole-1-carboxylate (0.083 g, 0.299 mmol) was reacted with N-(2-azidoethyl)-2-iodobenzamide (0.095 g, 0.299 mmol) following the general click procedure to give tert-butyl 2-amino-4-(5-(1-(2-(2-iodobenzamido)ethyl)-1H-1,2,3-triazol-4-yl)pentyl)-1H-imidazole-1-carboxylate 1H NMR (300 MHz, CDCl3) δ 7.74 (d, J=7.5 Hz, 2H), δ 7.57 (t, J=4.5 Hz, 1H), δ 7.36 (s, 1H), δ 7.22 (s, 2H), δ 6.97 (m, 1H), δ 6.39 (s, 1H), δ 5.97 (s, 2H), δ 4.48 (t, J=5.1 Hz, 2H), δ 3.85 (m, 2H), δ 2.44 (t, J=7.5 Hz, 2H), δ 2.18 (t, J=6.6 Hz, 2H), δ 1.45 (m, 13H, δ 1.18 (m, 2H) ppm; 13C NMR (75 MHz, CDCl3) δ 170.3, 150.4, 149.5, 148.2, 141.8, 139.9, 138.7, 131.3, 128.4, 128.3, 122.3, 106.5, 92.8, 84.9, 49.2, 40.5, 29.2, 28.9, 28.3, 28.2, 28.0, 25.5 ppm; HRMS (ESI) calcd for C24H321N7O3 (M+) 593.1611. found 593.1603, which was subsequently deprotected to give N-(2-(4-(5-(2-amino-1H-imidazol-4-yl)pentyl)-1H-1,2,3-triazol-1-yl)ethyl)-2-iodobenzamide hydrochloride (0.125 g, 79% yield). 1H NMR (400 MHz, CD3OD) δ 8.35 (s, 1H), δ 7.88 (d, J=7.8 Hz, 1H), δ 7.45 (t, J=6.9 Hz, 1H), δ 7.34 (d, J=6.9 Hz, 1H), δ 7.15 (t, J=7.5 Hz, 1H), δ 6.47 (s, 1H), δ 4.78 (s, 2H), δ 3.99 (s, 2H), δ 2.83 (s, 2H), δ 2.44 (t, J=6.9 Hz, 2H), δ 1.76 (s, 2H), δ 1.64 (s, 2H), δ 1.29 (s, 2H) ppm; 13C NMR (75 MHz, CD3OD) δ 171.6, 159.2, 147.3, 142.1, 139.8, 131.2, 128.2, 127.7, 124.4, 92.1, 52.2, 40.8, 39.4, 31.2, 28.3, 28.1, 27.7, 24.1, 20.9, 15.9, 10.7 ppm; HRMS (ESI) calcd for C19H24IN7O (M+) 493.1087. found 493.1085.

Sources & evidence

ORD record
ord-71fba7f36b5c4f71bf9496dd6e0168bb
Source dataset
uspto-grants-2016_05
Patent number
US09351491B2

Reaction notes

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