Ethyl diazoacetate → HCID 178468948, compound

HRID 529967Notes

Reaction equation

HRID 529967 reaction equation
[CH3:1][C:2](=[O:5])[C:3]#[CH:4].[CH2:6]([O:8][C:9](=[O:13])[CH:10]=[N+:11]=[N-:12])[CH3:7]>O>[CH2:6]([O:8][C:9]([C:10]1[CH:4]=[C:3]([C:2](=[O:5])[CH3:1])[NH:12][N:11]=1)=[O:13])[CH3:7]

Participants

4

Reactant 2

HCID 12192Ethyl diazoacetateHCID 15018Butyn-2-one

Product 1

HCID 178468948HCID 178468948, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

But-3-yn-2-one (Int 5, 1 eq) and diazo-acetic acid ethyl ester (Int 6, 1.1 eq) are added to a solution of InCl3 (0.2 eq) in water and stirred for 30 min at room temperature. After overnight stirring at room temperature, the mixture is diluted with water and extracted with EtOAc. The resulting organic phase is dried and evaporated to give the desired product.

Workup

  1. stirringAfter overnight stirring at room temperature
  2. extractionextracted with EtOAc
  3. customThe resulting organic phase is dried
  4. customevaporated

Sources & evidence

ORD record
ord-ebb2cc9e4ff5470eb76d76b2b6eefa5a
Source dataset
uspto-grants-2016_05
Patent number
US09351955B2

Reaction notes

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