Sodium Hydroxide → HCID 178467662, compound

HRID 52997Notes

Reaction equation

HRID 52997 reaction equation
[CH2:1]([O:3][CH2:4][C:5]1[N:6]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]3[NH:36][N:35]=[N:34][N:33]=3)=[CH:22][CH:21]=2)[C:7]([C:14]([O:16]CC)=[O:15])=[C:8]([C:10]([OH:13])([CH3:12])[CH3:11])[N:9]=1)[CH3:2].[OH-].[Na+]>>[CH2:1]([O:3][CH2:4][C:5]1[N:6]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]3[NH:36][N:35]=[N:34][N:33]=3)=[CH:22][CH:21]=2)[C:7]([C:14]([OH:16])=[O:15])=[C:8]([C:10]([OH:13])([CH3:12])[CH3:11])[N:9]=1)[CH3:2]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 178467659HCID 178467659, compound

Product 1

HCID 178467662HCID 178467662, compoundYield 79.8%

Procedure

A solution of 400 mg of ethyl 2-ethoxymethyl-4-(1-hydroxy-1-methylethyl)-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate [prepared as described in Example 86(b)] in 3.5 ml of a 1N aqueous solution of sodium hydroxide was stirred at room temperature for 1 hour. Insoluble matter was then filtered off, and 3.5 ml of 1N aqueous hydrochloric acid were added to the filtrate. The amorphous powder which precipitated was collected, to give 301 mg of the title compound, melting at 150° C. (with softening).

Workup

  1. filtrationInsoluble matter was then filtered off
  2. addition3.5 ml of 1N aqueous hydrochloric acid were added to the filtrate
  3. customThe amorphous powder which precipitated
  4. customwas collected

Sources & evidence

ORD record
ord-e9bcc6bda4114bb28926d537f0b1de8a
Source dataset
uspto-grants-1997_04
Patent number
US05616599

Reaction notes

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