Bromine → 2-Bromo-2'-chloroacetophenone

HRID 529982ノート

反応式

HRID 529982 の反応式
[Br:1]Br.[Cl:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10](=[O:12])[CH3:11]>C(O)(=O)C>[Br:1][CH2:11][C:10]([C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[Cl:3])=[O:12]

参加物

4

反応物 2

HCID 24408BromineHCID 72864Ethanone, 1-(2-chlorophenyl)-

生成物 1

HCID 27357852-Bromo-2'-chloroacetophenone

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Bromine (3.8 mL, 65 mmol) was added dropwise to a solution, of 1-(2-chloro-phenyl)-ethanone (10 g, 65 mmol) in acetic acid (75 mL) at 0° C. The mixture was then warmed to room temperature and stirred overnight. The mixture was evaporated to dryness and used in the next step without further purification.

後処理

  1. customThe mixture was evaporated to dryness
  2. customused in the next step without further purification

出典と根拠

ORDレコード
ord-571fb7e1362d4f5b831f72ece666df31
出典データセット
uspto-grants-2016_05
特許番号
US09351962B2

反応ノート

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