Water → (2,2-Difluoro-1,3-dioxaindan-5-yl)methanol

Participants

Reaction Steps

To a suspension of LAH (12.6 g, 0.33 mol) in THF (100 mL) was added dropwise a solution of 2,2-difluorobenzo-1,3dioxole-5-carboxylic acid (30 g, 0.15 mol) in THF (200 mL) at 0□ under N2. The mixture was allowed to warm to room temperature and stirred for one hour at this temperature. Then, water (12.6 g) and aq. NaOH (10%, 12.6 g) were added dropwise at 0□. The resulting mixture was filtered. The filtrate was dried over anhydrous Na2SO4 and evaporated under vacuum to give crude (2,2-difluoro-1,3-benzodioxol-5-yl)methanol (25.5 g, 91.3%), which was used directly in the next step.

Provenance & Evidence