HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfur → 3-Bromo-4-cyclopropyl-5-fluoropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfur | HCID 5362487 | — |
| Reactant | 3-Bromo-4-cyclopropyl-5-fluoro-4H-pyridine-1-carboxylic acid phenyl ester | HCID 86729650 | — |
| Solvent | Decalin | HCID 7044 | — |
| Product | 3-Bromo-4-cyclopropyl-5-fluoropyridine | HCID 71743363 | — |
Reaction Steps
A mixture of the crude phenyl 3-bromo-4-cyclopropyl-5-fluoropyridine-1 (4H)-carboxylate (1.14 g, 0.0034 mol) and sulphur (0.108 g, 0.0034 mol) were heated at reflux in DECALIN (10 mL) for a period of 3 h, then cooled to room temperature. Purification by silica gel chromatography, eluting first with hexanes, then with a 2-5% ethyl acetate-hexane gradient, gave the title compound. MS (M+1): 217.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09351973B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-4539eedb92d947328275f419d474cd99 |
| Source note | uspto-grants-2016_05 |