Sulfuric Acid → HCID 86665990, compound

Participants

Reaction Steps

N-(4,6-bis-propylamino-[1,3,5]triazin-2-yl)-O-ethyl-N-methyl-hydroxylamine (XCVI) was reacted with 95% H2SO4 as described in Example 20, to afford (XCVII) in 91% yield. 400 MHz 1H NMR (DMSO-d6, ppm) 11.7-10.8 (1H, br s), 8.79-7.34 (2H, m), 4.09-3.98 (2H, m), 3.40-3.20 (7H, m), 1.61-1.46 9 (4H, m), 1.27 (3H, t, J=7.1 Hz), 0.94-0.84 (6H, m). 400 MHz 1H NMR (D2O, ppm) 3.99-3.88 (2H, m), 3.34-3.13 (7H, m), 1.52-1.39 (4H, m), 1.14 (3H, t, J=7.1 Hz), 0.76 (6H, t, J=7.5 Hz). ESI-MS (m/z): 269 [M+H]+. M.P.: 84-86° C.

Provenance & Evidence