Hydrochloric Acid → HCID 85994846, compound

Participants

Reaction Steps

To a stirred solution of methyl N-(2-chloro-5-nitropyrimidin-4-yl)-2-methyl-N-(3-methylbutyl)alaninate (2.0 g, 5.8 mmol) in ethanol (125 mL) was added iron powder (3.2 g, 58 mmol), the resulting mixture was heated to reflux. 1N aqueous hydrochloric acid was added to the reaction mixture (added in small portions, 5.0 ml total), The reaction mixture was heated at reflux until the completion of the reaction as monitored by TLC. The reaction was cooled to room temperature and filtered. The filtrate was evaporated to give a residue which was triturated using isopropyl ether to give titled compound (yield: 65%). 1HNMR (300 MHz, CDCl3): δ 0.97 (s, 3H), 1.0 (s, 3H), 1.37-1.56 (m, 7H), 1.65-1.80 (m, 2H), 3.52-3.58 (m, 2H), 7.62 (s, 1H), 9.13 (br s, 1H).

Provenance & Evidence