HCID 68672578, compound → HCID 89560938, compound

HRID 530113Notes

Reaction equation

HRID 530113 reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]2[N:8]([C:12]3[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=3)[C:15]#[N:16])[C:7](=[O:20])[C@@H:6]([CH2:21][F:22])[N:5]([CH:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[C:4]=2[N:3]=1.[F:28][C:29]1[CH:30]=[C:31]([NH2:38])[CH:32]=[C:33]2[C:37]=1[NH:36][N:35]=[CH:34]2>>[CH:23]1([N:5]2[C:4]3[N:3]=[C:2]([NH:38][C:31]4[CH:32]=[C:33]5[C:37](=[C:29]([F:28])[CH:30]=4)[NH:36][N:35]=[CH:34]5)[N:11]=[CH:10][C:9]=3[N:8]([C:12]3[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=3)[C:15]#[N:16])[C:7](=[O:20])[C@H:6]2[CH2:21][F:22])[CH2:27][CH2:26][CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 68672578HCID 68672578, compoundHCID 89570397HCID 89570397, compound

Product 1

HCID 89560938HCID 89560938, compound

Procedure

This compound was prepared from 3-[(7S)-2-chloro-8-cyclopentyl-7-(fluoromethyl)-6-oxo-7,8-dihydropteridin-5(6H)-yl]benzonitrile and 7-fluoro-1H-indazol-5-amine, according to procedures similar to step e for the preparation of Example 18.

Workup

  1. customaccording to procedures similar to step e for the preparation of Example 18

Sources & evidence

ORD record
ord-c9fe76d56f6e4120bb60a44d36a9c59a
Source dataset
uspto-grants-2016_05
Patent number
US09351974B2

Reaction notes

Loading…