3-Pyridinylboronic acid → HCID 117653869, compound

HRID 530123Notes

Reaction equation

HRID 530123 reaction equation
[Cl:1][C:2]1[N:11]=[CH:10][C:9]2[NH:8][C:7](=[O:12])[C@@H:6]([CH3:13])[N:5]([CH:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)[C:4]=2[N:3]=1.[N:20]1[CH:25]=[CH:24][CH:23]=[C:22](B(O)O)[CH:21]=1>>[Cl:1][C:2]1[N:11]=[CH:10][C:9]2[N:8]([C:22]3[CH:21]=[N:20][CH:25]=[CH:24][CH:23]=3)[C:7](=[O:12])[C@@H:6]([CH3:13])[N:5]([CH:14]3[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]3)[C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 27343783-Pyridinylboronic acidHCID 89570508HCID 89570508, compound

Product 1

HCID 117653869HCID 117653869, compound

Procedure

(7R)-2-chloro-8-cyclohexyl-7-methyl-5-(pyridin-3-yl)-7,8-dihydropteridin-6(5H)-one was prepared from (7R)-2-chloro-8-cyclohexyl-7-methyl-7,8-dihydropteridin-6(5H)-one and pyridin-3-ylboronic acid, according to procedures similar to step d for the preparation of Example 18. Examples 304 was prepared according to procedures similar to the preparation of Example 303, using corresponding starting materials and intermediates.

Workup

  1. customaccording to procedures similar to step d for the preparation of Example 18
  2. customExamples 304 was prepared
  3. customaccording to procedures similar to the preparation of Example 303

Sources & evidence

ORD record
ord-d3cfe09bf8624ae0b48201606441a1de
Source dataset
uspto-grants-2016_05
Patent number
US09351974B2

Reaction notes

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