Cyclopentylamine → HCID 117653765, compound

HRID 530128Notes

Reaction equation

HRID 530128 reaction equation
Cl[C:2]1[N:11]=[CH:10][C:9]2[N:8]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:7](=[O:18])[C:6](=[O:19])[N:5]([CH2:20][CH2:21][CH:22]([CH3:24])[CH3:23])[C:4]=2[N:3]=1.[NH2:25][C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[NH:31][N:30]=[CH:29]2.ClC1N=CC2N(C3C=CC=CC=3)C(=O)[C@@H](C)N(C3CCCCC3)C=2N=1.C1(N)CCCC1>>[NH:31]1[C:32]2[C:28](=[CH:27][C:26]([NH:25][C:2]3[N:11]=[CH:10][C:9]4[N:8]([C:12]5[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=5)[C:7](=[O:18])[C:6](=[O:19])[N:5]([CH2:20][CH2:21][CH:22]([CH3:24])[CH3:23])[C:4]=4[N:3]=3)=[CH:34][CH:33]=2)[CH:29]=[N:30]1

Participants

5

Reactant 4

HCID 2906CyclopentylamineHCID 880121H-Indazol-5-amineHCID 89560723HCID 89560723, compoundHCID 117653846HCID 117653846, compound

Product 1

HCID 117653765HCID 117653765, compound

Procedure

This compound was prepared from 2-chloro-8-(3-methylbutyl)-5-phenyl-5,8-dihydropteridine-6,7-dione and 5-aminoindazole, according to procedures similar to the preparation of example 18 from (7R)-2-chloro-8-cyclohexyl-7-methyl-5-phenyl-7,8-dihydropteridin-6(5H)-one. Examples 306 and 307 was prepared according to procedures similar for the preparation of Example 305, using corresponding starting materials and intermediates. For example, for synthesis of example 307, cyclopentanamine was used in the step a of the synthesis.

Workup

  1. customExamples 306 and 307 was prepared
  2. customaccording to procedures similar for the preparation of Example 305
  3. customof the synthesis

Sources & evidence

ORD record
ord-baec93b0d2ef491dacccc9a4ab5cc18a
Source dataset
uspto-grants-2016_05
Patent number
US09351974B2

Reaction notes

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