Dimethylformamide → (S)-1-(3-methoxyphenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium iodide

Participants

Reaction Conditions

Reaction Steps

Mix 5.5 g (0.02 mol) of (S)-1-(3-methoxyphenyl)-N-methyl-N—((S)-1-phenylethyl)ethanamine (formula IV) with 12 ml N,N-dimethylformamide and 14.2 g (0.1 mol) of methyl iodide at room temperature, heat the mixture to 60° C. for 12 hours. Let it cool to room temperature, and add 100 ml of ethyl acetate. A yellow solid is produced. Filter and dry it to receive 5.8 g light yellow solid with a yield of 70%.

Provenance & Evidence