Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 3-((S)-1-(Methyl((S)-1-phenylethyl)amino)ethyl)phenol | HCID 42604950 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86712421 | HCID 86712421 | 87% |
Reaction Steps
Mix 5.1 g (0.02 mol) of 3-[(S)-1-(methyl-[(S)-1-phenylethyl]amino)ethyl]phenol (formula V) with 10 ml of methanol and 11.3 g (0.08 mol) of methyl iodide at room temperature, and heat the mixture to 60° C. for 10 hours. Cool it to room temperature and add 100 ml of ethyl acetate. A yellow solid is produced. Filter and dry it to receive 6.9 g yellow solid with a yield of 87%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09353049B2 |
|---|
| Source dataset | uspto-grants-2016_05 |
|---|
| ORD ID | ord-68b81f96f9db40d39d4467262dd05e4e |
|---|
| Source note | uspto-grants-2016_05 |
|---|
