HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium iodide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-Ethyl-N-methylcarbamoyl chloride | HCID 11240471 | — |
| Reactant | HCID 86712421 | HCID 86712421 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Product | (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium iodide | HCID 86712425 | — |
Reaction Steps
Mix 7.9 g (0.02 mol) (S)-1-(3-hydroxyphenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium iodide (formula VIII) with 180 ml of acetonitrile, 4.1 g (0.03 mol) of potassium carbonate, 3.6 g (0.03 mol) ethyl(methyl)carbamic chloride and 0.1 g of macrogol 400 at room temperature, let it react at 20° C. for 16 hours. Filter it and reduce the pressure to recover 9.8 g of red-brown liquid to be directly used in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353049B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-f00945fe4f2342b592132763fe1b5421 |
| Source note | uspto-grants-2016_05 |