HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 530208Generated: November 2, 2026
Potassium Carbonate → (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium iodide
https://huagongshe.com/reaction/530208
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-Ethyl-N-methylcarbamoyl chloride | HCID 11240471 | — |
| Reactant | HCID 86712421 | HCID 86712421 | — |
| Catalyst | Tetrabutylammonium Bromide | HCID 74236 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium iodide | HCID 86712425 | — |
Reaction Steps
Mix 7.9 g (0.02 mol) of(S)-1-(3-hydroxyphenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium iodide (formula VIII) with 180 ml of acetonitrile, 4.1 g (0.03 mol) of potassium carbonate, 3.6 (0.03 mol) ethyl(methyl)carbamic chloride and 0.1 g of tetrabutylammonium bromide at room temperature, heat it to 60° C. and react it for 12 hours. After it is cooled to room temperature, filter it and reduce the pressure to recover the solvent and receive 9.5 g of red-brown liquid to be directly used in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09353049B2 |
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| Source dataset | uspto-grants-2016_05 |
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| ORD ID | ord-e59c03e08c4843459862ec30a5c6a136 |
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| Source note | uspto-grants-2016_05 |
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