反应详情

温度

60 °C

A suspension of 1.78 g of 4-acetyl-2-butyl-5-cyano-1-tritylimidazole [prepared as described in step (ii) above] in 80% v/v aqueous acetic acid was stirred at 60° C. for 1 hour. The solution thus obtained was concentrated to dryness by evaporation under reduced pressure. The resulting residue was purified by column chromatography through silica gel, using a 3:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 0.66 g of the title compound as a colorless solid, melting at 77°-78° C.

1. customThe solution thus obtained
2. concentrationwas concentrated to dryness by evaporation under reduced pressure
3. customThe resulting residue was purified by column chromatography through silica gel
4. additionby volume mixture of hexane and ethyl acetate as the eluent