1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → HCID 178510310, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (E)-ethyl 2-cyano-3-((4-nitrophenyl)amino)acrylate (24.0 g) and Dowtherm A (500 mL) was added to a 1 L flask, the mixture was heated to reflux under nitrogen for 10 hours. After cooling to 50° C., the mixture was diluted with hexane (1 L). The product was filtered, washed with ethanol (100×2 mL), and dried to give 4-hydroxy-6-nitroquinoline-3-carbonitrile (Compound 16) as a brown solid (12.0 g).

Provenance & Evidence