Water → HCID 89852229, compound

Participants

Reaction Steps

A mixture of -chloro-6-nitroquinoline-3-carbonitrile (4.1 g, 17.6 mmol, 1.0 eq), 4-phenoxyaniline (2.6 g, 14.1 mmol, 0.8 eq) was dissolved in ethanol (40 mL). The reaction was heated to reflux for 2 hours, cooled to room temperature, poured into water (50 mL), and washed with ethyl acetate (50×2 mL). It was filtrated and dried in vacuum to give 6-nitro-4-((4-phenoxyphenyl)amino)quinoline-3-carbonitrile (Compound 18) as a solid (5.6 g)

Provenance & Evidence