Triethylamine → HCID 71767957, compound

Participants

Reaction Steps

Example 3 was prepared as an off-white solid using a procedure similar to that described for the synthesis of compound 21 (Example 2). Triethylamine (1.03 g, 10.2 mmol, 1.2 eq) and acryloyl chloride (926 mg, 10.2 mmol, 1.2 eq) were added to an ice cold solution of 6-amino-4-((4-phenoxyphenyl)amino)quinoline-3-carbonitrile (3.0 g, 8.5 mmol, 1.0 eq) in THF (50 mL) under nitrogen. The reaction was stirred at rt for 2 hours. The water was added. The water layer was extracted with EA, dried over anhydrous sodium sulfate. The crude product was purified by column chromatography on silica gel to give N-(3-cyano-4-((4-phenoxyphenyl)amino)quinolin-6-yl)acrylamide as an off-white solid 1.2 g.

Provenance & Evidence