Pyrrolidine → 2-Bromo-2,2-difluoro-1-(pyrrolidin-1-yl)ethanone

Participants

Reaction Steps

Pyrrolidine (7.7 g, 108 mmol) was added to ethyl bromodifluoroacetate (20.2 g, 100 mmol) at 30° C. The mixture was stirred for 60 min; then all volatiles were removed under reduced pressure and the residue (24.0 g, >90% purity by NMR) was used in subsequent steps without further purification.

Provenance & Evidence