HCID 178441657, compound → HCID 178441749, compound

HRID 53036Notes

Reaction equation

HRID 53036 reaction equation
[C:1]([C:4]1[N:5]=[C:6]([CH2:11][CH2:12][CH2:13][CH3:14])[NH:7][C:8]=1[C:9]#[N:10])(=[O:3])[CH3:2].[CH2:15]([Mg]Br)[CH2:16]C>>[CH2:11]([C:6]1[NH:7][C:8]([C:9]#[N:10])=[C:4]([C:1](=[O:3])[CH2:2][CH2:15][CH3:16])[N:5]=1)[CH2:12][CH2:13][CH3:14]

Participants

3

Reactant 2

HCID 178441657HCID 178441657, compoundHCID 178455851HCID 178455851, compound

Product 1

HCID 178441749HCID 178441749, compoundYield 57.2%

Procedure

Following a procedure similar to that described in Preparation 24(i), but using propylmagnesium bromide instead of methylmagnesium bromide, the title compound, melting at 91°-92° C., was obtained in a 57.2% yield.

Sources & evidence

ORD record
ord-ecc066aa9b944033836e3bcde809b0b8
Source dataset
uspto-grants-1997_04
Patent number
US05616599

Reaction notes

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