2-propyl-1H-imidazole-4,5-dicarbonitrile → HCID 178450364, compound

HRID 53037Notes

Reaction equation

HRID 53037 reaction equation
[C:1]([C:4]1[N:5]=[C:6]([CH2:11][CH2:12][CH2:13]C)[NH:7][C:8]=1[C:9]#[N:10])(=[O:3])[CH3:2].[CH2:15](C1NC(C#N)=C(C#N)N=1)[CH2:16]C.C([Mg]Br)CC>>[C:1]([C:4]1[N:5]=[C:6]([CH2:11][CH2:12][CH3:13])[NH:7][C:8]=1[C:9]#[N:10])(=[O:3])[CH2:2][CH2:15][CH3:16]

Participants

4

Reactant 3

HCID 27637212-propyl-1H-imidazole-4,5-dicarbonitrileHCID 178441657HCID 178441657, compoundHCID 178455851HCID 178455851, compound

Product 1

HCID 178450364HCID 178450364, compoundYield 49.8%

Procedure

Following a procedure similar to that described in Preparation 24(i), but using 2-propylimidazole-4,5-dicarbonitrile (prepared as described in Preparation 10) and propylmagnesium bromide, the title compound, melting at 94°-95° C., was obtained in a 49.8% yield.

Sources & evidence

ORD record
ord-57dbebaf2cb5498081be82cf04d0bd01
Source dataset
uspto-grants-1997_04
Patent number
US05616599

Reaction notes

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