Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromo-5,6,7,8-tetrahydroisoquinolin-8-OL → 3,4-Dihydro-1-methyl-6-(5,6,7,8-tetrahydro-8-hydroxy-4-isoquinolinyl)-2(1H)-quinolinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromo-5,6,7,8-tetrahydroisoquinolin-8-OL | HCID 71743891 | — |
| 반응물 | 1-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroquinolin-2(1H)-one | HCID 72208233 | — |
| 생성물 | 3,4-Dihydro-1-methyl-6-(5,6,7,8-tetrahydro-8-hydroxy-4-isoquinolinyl)-2(1H)-quinolinone | HCID 71506888 | — |
반응 단계
In analogy to the procedure described for the preparation of intermediate A-2 [E], Suzuki reaction of (rac)-4-bromo-5,6,7,8-tetrahydro-isoquinolin-8-ol with 1-methyl-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-1H-quinolin-2-one (intermediate A-1) gave the title compound as light red powder. MS: 309.5 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09353081B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-97172c900b18493497b8d66fd5ad77ac |
| 출처 메모 | uspto-grants-2016_05 |