HCID 90041922, compound → HCID 90042217, compound

Participants

Reaction Steps

Pd/C (53.9 mg, 0.051 mmol) was added to a solution of 4-(5-nitrobiphenyl-3-yl)morpholine (144 mg, 0.506 mmol) in ethyl acetate (5 mL) and acetic acid (0.5 mL). The reaction mixture was stirred under H2 atmosphere (1 atm) for 2 hours at room temperature. The reaction mixture was diluted with dichloromethane and filtered through CELITE and washed with ethyl acetate. The resultant solution was concentrated in vacuo to provide 5-(morpholin-4-yl)biphenyl-3-amine as a grey solid which was used without further purification. 1H NMR (400 MHz, CDCl3) δ 7.57 (d, J=5.7 Hz, 2H), 7.36 (dd, J=32.4, 26.2 Hz, 3H), 6.58 (s, 1H), 6.49 (s, 1H), 6.27 (s, 1H), 5.13 (s, 2H), 3.89 (s, 4H), 3.21 (s, 4H).

Provenance & Evidence