HCID 121261628, compound → HCID 121261625, compound

Participants

Reaction Conditions

Reaction Steps

To a degassed solution of tert-butyl[5-({2-[(aminocarbonyl)amino]phenyl}ethynyl)-3-thienyl]carbamate (112 mg, 0.314 mmol, 1 eq) in anhydrous acetonitrile (2 mL) was added bis(acetonitrile)dichloropalladium(II) (16.3 mg, 0.2 eq). After the reaction mixture was heated at 90° C. for 50 minutes, it was cooled to room temp, and diluted with ethyl acetate. The mixture was washed with aqueous ammonium chloride, water, and brine, and lastly dried with anhydrous sodium sulfate. The upper solution was decanted, concentrated, and the dark brown mixture was subject to a gradient column chromatography (EtOAc-hex from 1; 100 to 1:5) to yield tert-butyl {5-[1-(aminocarbonyl)-1H-indol-2-yl]-3-thienyl}carbamate as white powder in amount of 23 mg.

Provenance & Evidence