反应详情

In a pear flask, at rt, ethyl (2S*,3R*)-2-(dibenzylamino)-3-hydroxy-pentanoate (0.165 g, 0.48 mmol) was dissolved in EtOH (12 mL) and passed through the H-Cube® hydrogenator flow reactor, using 10% Pd/C as catalyst [flow:1.0 mL/min; P=1.0 bar, T=70° C.]. After evaporation of the solvent, the title compound was obtained as yellowish oil and used without further purification in the following step. MS (ESI) m/z: 162 [M−H]+.

1. custom[flow:1.0 mL/min; P=1.0 bar, T=70° C.]
2. customAfter evaporation of the solvent