Sodium Azide → HCID 117871823, compound

Participants

Reaction Conditions

Reaction Steps

(R)-2-(4-Fluoro-3-(trifluoromethyl)phenyl)-2-hydroxyethyl 4-methylbenzenesulfonate (3.5 g, 9.25 mmol) was dissolved in 20 mL of DMSO. Sodium azide (1.2 g, 18.5 mmol) was added and the mixture was stirred at 80° C. for 3 h. The clear solution was cooled to room temperature and extracted with ethyl acetate and water. The organic layer was dried and concentrated to give (R)-2-azido-1-(4-fluoro-3-trifluoromethylphenyl)-ethanol as a pale brown oil (2.27 g) which was used as is in the next step.

Provenance & Evidence