HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 530595Generated: November 2, 2026
Triethylamine → (S)-3-((R)-2-(3-chlorophenyl)morpholino)-1,1,1-trifluoropropan-2-ol
https://huagongshe.com/reaction/530595
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (2S)-2-(Trifluoromethyl)oxirane | HCID 7171781 | — |
| Reactant | (R)-2-(3-chloro-phenyl)-morpholine hydrochloride | HCID 117869899 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (S)-3-((R)-2-(3-chlorophenyl)morpholino)-1,1,1-trifluoropropan-2-ol | HCID 117872579 | 100.1% |
Reaction Steps
To a solution of (R)-2-(3-chloro-phenyl)-morpholine hydrochloride (45 mg, 192 μmol) and triethylamine (134 μL, 961 μmole) in 4 mL of acetonitrile was added (S)-2-(trifluoromethyl)oxirane (43.1 mg, 384 μmol). The mixture was stirred at 50° C. for 3 h, followed by evaporation in vacuo to afford (S)-3-((R)-2-(3-chlorophenyl)morpholino)-1,1,1-trifluoropropan-2-ol (59.5 mg), which was used directly for next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09353096B2 |
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| Source dataset | uspto-grants-2016_05 |
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| ORD ID | ord-7c6fd793f5554079818357ab2262f362 |
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| Source note | uspto-grants-2016_05 |
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