2-Benzylmorpholine → (S)-3-(2-benzyl-morpholin-4-yl)-1,1,1-trifluoro-propan-2-ol

Participants

Reaction Steps

In a 25 mL round-bottom flask was placed 2-benzylmorpholine (354 mg, 2 mmol), followed by (S)-2-(trifluoromethyl)oxirane (224 mg, 2 mmol). The mixture was stirred for 30 min. Another 100 uL of (S)-2-(trifluoromethyl)oxirane was added. Reaction mixture was continued at room temperature overnight, then concentrated in vacuo to afford (S)-3-(2-benzyl-morpholin-4-yl)-1,1,1-trifluoro-propan-2-ol a colorless oil (600 mg).

Provenance & Evidence