Nitromethane → HCID 67360344, compound

Participants

Reaction Steps

In a 100 mL round-bottomed flask, 6-(trifluoromethyl)nicotinaldehyde (2.61 g, 14.9 mmol) was combined with nitromethane (20 ml) to give a light yellow solution. triethylamine (1.51 g, 2.08 ml, 14.9 mmol) was added. The reaction mixture was stirred at room temperature for 1.5 h and concentrated in vacuo. The resultant residue was purified by flash chromatography (silica gel, 80 g, 0.2% to 1.2% MeOH in dichloromethane gradient) to afford 2-nitro-1-(6-(trifluoromethyl)pyridin-3-yl)ethanol (2.4 g) as an off-white solid.

Provenance & Evidence