3-Chloro-4-methylphenyl isocyanate → HCID 118288518, compound

Participants

Reaction Steps

(S)-1,1,1-Trifluoro-3-[2-(4-trifluoromethyl-phenyl)-morpholin-4-yl]-propan-2-ol (50 mg, 146 μmol) and 2-chloro-4-isocyanato-1-methylbenzene (prepared by a similar procedure as for intermediate A, 24.4 mg, 146 μmol) were combined in acetonitrile (1 mL). A mixture was stirred at room temperature overnight and evaporated. The residue was purified by flash chromatography (20% EtOAc/hexanes) to provide (3-chloro-4-methylphenyl)-carbamic acid (S)-2,2,2-trifluoro-1-[2-(4-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-ethyl ester, which was converted to the HCl salt to afford (3-chloro-4-methylphenyl)-carbamic acid (S)-2,2,2-trifluoro-1-[2-(4-trifluoromethyl-phenyl)-morpholin-4-ylmethyl]-ethyl ester hydrochloride as a white solid (15 mg). (M+H)+=511 m/e.

Provenance & Evidence