Morpholine → HCID 4422171, compound

HRID 530634Notes

Reaction equation

HRID 530634 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[F:7][C:8]([F:13])([F:12])[CH:9]1[O:11][CH2:10]1>>[F:7][C:8]([F:13])([F:12])[CH:9]([OH:11])[CH2:10][N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 5207692-(Trifluoromethyl)oxirane

Product 1

HCID 4422171HCID 4422171, compoundYield 98%

Procedure

To a round bottomed flask containing 3.136 g (36 mmol) of morpholine was added 3.362 g (30 mmol) of racemic 1,1,1-trifluoro-2,3-epoxypropane dropwise over 10 min (exothermic). The mixture was stirred at room temperature. After 90 min, the volatiles were removed under reduced pressure to give 5.837 g (98%) of 1,1,1-trifluoro-3-morpholin-4-yl-propan-2-ol as an oil.

Workup

  1. customthe volatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-15724211ebdf403e94ea3df04fcde573
Source dataset
uspto-grants-2016_05
Patent number
US09353096B2

Reaction notes

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