HRID530652

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57775250

未命名化合物

结构：COc1c(Br)cc(-c2cnc(OC(C)(C)C)nc2OC(C)(C)C)cc1C(C)(C)C

HCID66833848

未命名化合物

PRODUCTS

生成物

结构：COc1c(/C=C/c2ccc(NS(C)(=O)=O)cc2)cc(-c2cnc(OC(C)(C)C)nc2OC(C)(C)C)cc1C(C)(C)C

HCID66833874

未命名化合物

PROCEDURE

实验过程

The product from Example 2 Part A (55.9 mg, 0.12 mmol) and (E)-4-(methylsulfonamido) styrylboronic acid (28.9 mg, 0.120 mmol) were reacted in the same manner as Example 2 Step B. The crude product was purified by silica gel flash chromatography eluting with ethyl acetate/hexane (5% to 25%) to give the title compound.

WORKUP

后处理

customThe crude product was purified by silica gel flash chromatography
washeluting with ethyl acetate/hexane (5% to 25%)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-819a18f8c79d40e8be5c19e818228777
来源数据集: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09353091B2
来源说明: uspto-grants-2016_05

反应 SMILES

Br[C:2]1[CH:3]=[C:4]([C:14]2[C:15]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[N:16][C:17]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[N:18][CH:19]=2)[CH:5]=[C:6]([C:10]([CH3:13])([CH3:12])[CH3:11])[C:7]=1[O:8][CH3:9].[CH3:30][S:31]([NH:34][C:35]1[CH:45]=[CH:44][C:38](/[CH:39]=[CH:40]/B(O)O)=[CH:37][CH:36]=1)(=[O:33])=[O:32]>>[C:10]([C:6]1[C:7]([O:8][CH3:9])=[C:2]([CH:3]=[C:4]([C:14]2[C:15]([O:25][C:26]([CH3:29])([CH3:27])[CH3:28])=[N:16][C:17]([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[N:18][CH:19]=2)[CH:5]=1)/[CH:40]=[CH:39]/[C:38]1[CH:37]=[CH:36][C:35]([NH:34][S:31]([CH3:30])(=[O:32])=[O:33])=[CH:45][CH:44]=1)([CH3:12])([CH3:13])[CH3:11]