HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 73442650, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1H,3H,4H,5H,6H-cyclopenta(c)furan-1,3-dione | HCID 324854 | — |
| Reactant | 2-Amino-3-phenyl-thiophene | HCID 23464302 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 73442650 | HCID 73442650 | 36% |
Reaction Steps
3-Phenyl-thiophen-2-ylamine (73 mg, 417 μmol, Int1.1), NEt3 (84.3 mg, 116 μL, 833 μmol) and 1-cyclopentene-1,2-dicarboxylic anhydride (144 mg, 1.04 mmol) were dissolved in dry THF (3 mL). The green-yellow suspension was stirred at RT over the week-end and filtered. The filtrate was concentrated in vacuo and the residue was purified by preparative HPLC (MeOH/H2O with 0.1% formic acid) to give the title compound as a yellow oil (47 mg, 32%, purity estimated at 90%). MS (ESI): m/z=312.2 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353102B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-f3305fdac30b41afa7ceca56cf863722 |
| Source note | uspto-grants-2016_05 |