3-Methoxyaniline → 2'-Amino-3'-methyl-4'-methoxyacetophenone

HRID 530710Notes

Reaction equation

[CH3:1][O:2][C:3]1[C:4]([CH3:10])=[C:5]([CH:7]=[CH:8][CH:9]=1)[NH2:6].C[O:12][C:13]1C=CC=C(N)[CH:14]=1>>[NH2:6][C:5]1[C:4]([CH3:10])=[C:3]([O:2][CH3:1])[CH:9]=[CH:8][C:7]=1[C:13](=[O:12])[CH3:14]

Participants

Reactant 2

HCID 108243-Methoxyaniline

HCID 118048223-Methoxy-2-methylaniline

Product 1

HCID 250673162'-Amino-3'-methyl-4'-methoxyacetophenoneYield 23%

Procedure

Compound 201b was synthesized from 3-methoxy-2-methylaniline 215b as a yellow solid in 23% yield, according to the procedure as described for compound 215a. MS (ESI, EI+): m/z=180 (MH+).

Sources & evidence

ORD record: ord-be2bfdf7a8e04d06ae22fa94b67d41a1
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09353100B2

Reaction notes

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