N-(6-Acetyl-3-methoxy-2-methylphenyl)-4-(propan-2-yl)-1,3-thiazole-2-carboxamide → 2-(4-Isopropylthiazol-2-YL)-7-methoxy-8-methylquinolin-4-OL

HRID 530719Notes

Reaction equation

HRID 530719 reaction equation
[C:1]([C:4]1[C:9]([NH:10][C:11]([C:13]2[S:14][CH:15]=[C:16]([CH:18]([CH3:20])[CH3:19])[N:17]=2)=O)=[C:8]([CH3:21])[C:7]([O:22][CH3:23])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].C(C1N=C(C2C=C(O)C3C(=CC(OC)=CC=3)N=2)SC=1)(C)C>>[CH:18]([C:16]1[N:17]=[C:13]([C:11]2[CH:2]=[C:1]([OH:3])[C:4]3[C:9](=[C:8]([CH3:21])[C:7]([O:22][CH3:23])=[CH:6][CH:5]=3)[N:10]=2)[S:14][CH:15]=1)([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 53482122N-(6-Acetyl-3-methoxy-2-methylphenyl)-4-(propan-2-yl)-1,3-thiazole-2-carboxamideHCID 178487691HCID 178487691, compound

Product 1

HCID 1784876922-(4-Isopropylthiazol-2-YL)-7-methoxy-8-methylquinolin-4-OLYield 60%

Procedure

Compound 218b was synthesized from compound 217b as a yellow solid in 60% yield, according to the procedure as described for compound 218a. MS (ESI, EI+): m/z=315 (MH+).

Sources & evidence

ORD record
ord-ca98e9fb58894701bce5c87b1265c253
Source dataset
uspto-grants-2016_05
Patent number
US09353100B2

Reaction notes

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