2,8-Dichloro-7-methoxy-4-(4-methoxy-benzyloxy)-quinoline → 2-Chloro-6-methoxy-4-(4-methoxybenzyloxy)-8-methyl-quinoline

Participants

Role	Name	HCID	Charge
Reactant	2,8-Dichloro-7-methoxy-4-(4-methoxy-benzyloxy)-quinoline	HCID 56605153	—
Reactant	2,4-Dichloro-6-methoxy-8-methyl-quinoline	HCID 86627750	—
Product	2-Chloro-6-methoxy-4-(4-methoxybenzyloxy)-8-methyl-quinoline	HCID 86627751	58%

Reaction Steps

Compound 221f was synthesized from compound 220f as a white solid in 58% yield, following the procedure as described for compound 221d. 1H NMR (CDCl3, 400 MHz) δ (ppm) 2.68 (s, 3H), 3.80 (s, 3H), 3.83 (s, 3H), 5.11 (s, 2H), 6.72 (s, 1H), 6.97 (d, J=9.03 Hz, 2H), 7.15 (dd, J=3.01 Hz and J=0.96 Hz, 1H), 7.20 (d, J=3.00 Hz, 1H), 7.40 (d, J=9.03 Hz, 2H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09353100B2
Source dataset	uspto-grants-2016_05
ORD ID	ord-9ae6169cf595439da753e86d197c927a
Source note	uspto-grants-2016_05