HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → N-(3-acetamido-4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)phenyl)-4-chlorobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Sodium bicarbonate methylene chloride | HCID 23716255 | — |
| Reactant | N-(3-amino-4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)phenyl)-4-chlorobenzamide | HCID 67464229 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(3-acetamido-4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)phenyl)-4-chlorobenzamide | HCID 67468600 | — |
Reaction Steps
To a solution of 17 (20 mg) in 2 ml DCM was added 3 eq DIEA and acetyl chloride (20 μl). The reaction mixture was stirred at r.t. for 5 h before worked up with DCM/NaHCO3, water. The org. phase was concentrated and subjected to prep HPLC purification to furnish compound 18.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353099B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-ba399b16958c44b09a0718e1c441ba64 |
| Source note | uspto-grants-2016_05 |