HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → (5-Chloro-6-methylpyridin-2-YL)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 5-Chloro-6-methylpyridine-2-carbonitrile | HCID 57336597 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | (5-Chloro-6-methylpyridin-2-YL)methanamine | HCID 72214042 | — |
Reaction Steps
To a mixture of 5-chloro-6-methylpicolinonitrile (3) (200 mg, 1.31 mmol) in MeOH (10 mL) was added NaBH4 (150 mg, 3.94 mmol), CoCl2 (5 mg) at room temperature. After 30 min, the mixture was filtered and purified by reverse phase chromatography (X bridge Prep C18OBD, 40-60% MeOH in water with 10 mmol NH4HCO3 modifier) to afford the compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09353104B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-04b217567ed54c7c9f8e2180148604cc |
| Source note | uspto-grants-2016_05 |