Ethyl diazoacetate → HCID 90419124, compound

HRID 530814Notes

Reaction equation

HRID 530814 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]=[CH2:12])=[N:3]1.[N+](=[CH:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[N-]>C1(C)C=CC=CC=1>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]2[CH2:12][CH:15]2[C:16]([O:18][CH2:19][CH3:20])=[O:17])=[N:3]1

Participants

4

Reactant 2

HCID 12192Ethyl diazoacetateHCID 206447223-Ethenyl-1-methyl-1h-indazole

Product 1

HCID 90419124HCID 90419124, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of compound 2 (1.1 g, 7 mmol) in toluene (5 mL) was treated with ethyl diazoacetate (1.2 g, 10 mmol) and stirred at reflux overnight under N2. The mixture was concentrated and the residue was purified by gradient elution on silica gel (PE: EA=5:1) to afford the title compound as a pale yellow oil.

Workup

  1. temperatureat reflux overnight under N2
  2. concentrationThe mixture was concentrated
  3. customthe residue was purified by gradient elution on silica gel (PE: EA=5:1)

Sources & evidence

ORD record
ord-6cd1060211504bde9583f4969f37471c
Source dataset
uspto-grants-2016_05
Patent number
US09353104B2

Reaction notes

Loading…