反应详情

温度

-20 °C

To a solution of compound 2 (3.8 g, 22 mmol) in toluene (20 mL) was added methylhydrazine (1.8 g, 0.039 mol) cooled to −20° C. After completion of the reaction, the reaction liquid was washed with water and the solvent was removed by evaporation to obtain crude product, the crude product was purified by silica gel column chromatography (PE:EA=5:1) to give the desired product as a white oil.

1. customAfter completion of the reaction
2. customthe reaction liquid
3. washwas washed with water
4. customthe solvent was removed by evaporation
5. customto obtain crude product
6. customthe crude product was purified by silica gel column chromatography (PE:EA=5:1)