Methyl iodide → HCID 90419149, compound

Participants

Reaction Steps

To a solution of compound 2 (100 mg, 0.20 mmol) in THF (20 mL) was added NaH (12 mg, 0.30 mmol) at 0° C. After stirred for 10 min, MeI (57 mg, 0.40 mmol) was added. The mixture was stirred for 2 h at room temperature and then diluted with H2O (20 mL) and EtOAc (50 mL). The organic phase was washed with H2O and brine, dried over Na2SO4, filtered and concentrated. The residue was purified by prep-TLC using PE/EtOAc=4/1 to give 4-((4-methoxybenzyl)((1-methyl-1H-1,2,3-triazol-4-yl)methyl)amino)-6-(((1S,2S)-2-(5-methoxypyridin-2-yl)cyclopropyl)methoxy)-2-methylpyridazin-3(2H)-one (3) (55 mg, yield: 53%) as a yellow solid and 4-((4-methoxybenzyl)((2-methyl-2H-1,2,3-triazol-4-yl)methyl)amino)-6-(((1S,2S)-2-(5-methoxypyridin-2-yl)cyclopropyl)methoxy)-2-methylpyridazin-3(2H)-one (4). ESI-MS: 461.2 (M+H)+.

Provenance & Evidence